How Antibiotic Dosage Regimens Based on Pk-pd Concepts May Be an Important Contribution to the Resistance Problem
نویسندگان
چکیده
The most important risk factor for emergence of resistance is repeated exposure of bacteria to suboptimal concentrations of antibiotics and thus, from an operational point of view, the most important risk factor for emergence of resistance is the selection of an inappropriate dosage regimen. There is therefore a need to design dosage schedules, not only to guarantee clinical efficacy, but also to minimize the emergence of such resistance. This is both a therapeutic issue (target pathogen) and a public health issue (non target bacteria) for veterinary antibiotherapy.
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